"The real danger is if people do not vote for the government this evening, we face either a no-deal Brexit, with the short-term economic damage that would bring, or worse: no Brexit at all", Gove told the BBC.
Even if parliament did agree in principle to a second referendum, Britain would then have to ask for an extension to its timetable for leaving the EU.
The DUP votes are crucial even if all Tory MPs vote in favor of the deal, as May will need at least four of the Northern Ireland party's votes.
Members of her Conservative party say the deal keeps Britain too close to the European Union, while opposition parties say fails to protect economic ties with the bloc.
In a sign of the widespread opposition, Parliament's unelected upper chamber, the House of Lords, voted by 321 to 152 late Monday in favor of a motion saying May's deal would damage Britain's economic prosperity, internal security and global influence, while also rejecting the idea of leaving the European Union without a deal.
Some of the hardline Brexiteers, including former Foreign Secretary Boris Johnson, former Brexit Secretary David Davis and staunch Remainer MP Anna Soubry, openly said they would reject the deal. He argued that elections would give a new government a mandate that would the break the deadlock in Brexit talks.
Downing Street insisted that it still wanted a Brexit that took back control of "our money, borders and laws" and that allowed an "independent trade policy".
One amendment from the opposition Labour Party rejects May's deal and rules out leaving the bloc without agreement.
"Many firms across Northern Ireland simply could not cope with a no-deal Brexit", said Angela McGowan, the director of the CBI's Northern Ireland branch.
Sterling rose 0.08% to $1.287 after declines of more than 1% earlier in the day.
Now, however, that's not the exit strategy the majority of MPs would want or would vote for, so the onus is really upon those MPs to negotiate or to find a deal that is acceptable to prevent that no deal, and that needs to be done: Parliament needs to act between now and the 29th of March in order to delay the Brexit day, in order to delay crashing out of the European Union without a deal - because the default option is we are going to crash out without a deal unless something can be agreed.
The call will spark a vote of no confidence, which will take place tomorrow.
Meanwhile, a leading Irish think tank warned in December that a no-deal Brexit would nearly halve Irish economic growth in 2019.
Prime Minister Theresa May listens to Labour leader Jeremy Corbyn speaking after losing a vote on her Brexit deal.
In the event of a defeat, the government must set out what happens next by Monday. But their words are unlikely to shift opposition to the deal. "That either means a general election or it means a people's vote - a second referendum in which the issues, the more complex issues around Brexit, are put to the people".
"It's pitting the government against parliament, and parliament against the people".
A number of amendments to the deal have been tabled by MPs ahead of Tuesday's vote. The result means her position as leader of the party can not be challenged for 12 months.
As anything other than a hard Brexit will be lengthy and complicated, the immediate outcome may be either exactly the "hard" exit with no agreement - or, some kind of extension to article 50 while the United Kingdom deals with the further turmoil.