Burton's Clough believes stopping Guardiola's City, particularly when they travel to the Etihad on Wednesday, is a tough task.
Some were surprised when Guardiola named such a strong team against third-tier opposition, but the selection comprehensively paid off as City virtually guaranteed themselves a spot in the final at Wembley Stadium.
"We didn't play brilliantly and a couple of the goals we were disappointed with, as we should have defended them better, but the gulf in quality was very evident and the players came in at half-time and were wide eyed with what they have played against".
"I think this one over two legs", said Clough, when asked to compare which was the tougher challenge. Scoring more is the best way to respect the competition and the opponent. "They know. They watch Match of the Day every week".
Arsenal will host Manchester United in the fourth round of the FA Cup after the draw was held following Wolves' 2-1 win against Liverpool on Monday night that sees Jurgen Klopp's team exit the competition.
"Some have followed the club for 40, 50, 60 years or more and never dreamt of being in a League Cup semi-final so let's enjoy it".
However, in eliminating Championship sides Aston Villa, Forest and Middlesbrough and Premier League strugglers Burnley, Burton have not yet faced any team of City's calibre.
"We've not gone into any detail with them because that will frighten the life out of them", admitted Clough. Having beaten four teams from higher divisions in the cup competition already this term, the Brewers will be aiming to cause a huge upset at the Etihad.
"We do what we have to do to become a great, great club", said the Spaniard.
It means City have scored 16 goals in four days after thrashing Rotherham United 7-0 in the third round of the FA Cup on Sunday.
Liverpool legend Jamie Carragher responded to a dig from a City supporter by tweeting: "You can't fill your Stadium!"
"In reality it's going to be hard but I'm sure all the players will go there in the right frame of mind".
Chelsea play Tottenham Hotspur this Tuesday in the first leg of their semi-final, live on Sky Sports Football, with the return leg scheduled for January 24. "You can not be 'oh, it's Burton" and we did not - that is why I'm pleased.