However, the first question from the audience was not about her economic agenda, but about the same old topic - her Native American lineage and controversial decision to take a DNA test that revealed it.
Politico ran a piece comparing Warren's likability issues to those of former Secretary of State Hillary Clinton.
In various speeches and question-and-answer sessions, Warren described her early campaign as a fight. The Cherokee Nation immediately slammed Warren for releasing the test, stating, "Using a DNA test to lay claim to any connection to the Cherokee Nation or any tribal nation, even vaguely, is inappropriate and wrong".
Senator Elizabeth Warren is making her rounds through Iowa this weekend with one stop Saturday morning in Sioux City.
Warren had a captive audience where she tested campaign themes of taking on major corporations, challenging government corruption and exploring economic inequity while weaving a personal narrative that focused on her family's financial struggles when growing up in Oklahoma.
She unveiled a raft of staff hires last week. Tribal citizenship is difference from ancestry. I am not a citizen of a tribe. And I like that, retired Sioux City teacher Colleen Sernett-Shadle said.
Warren said she wanted to "put it all out there" in public, but 2020 won't be "about my family", but millions of others "who just want a level playing field". Instead, 2020 can not get started soon enough, according to almost two dozen people who attended Warren events and talked to POLITICO.
He added, "The Republican Party of Iowa welcomes Republicans from across the country to come and visit our state and talk to our grassroots voters, but we are 100 percent behind President Donald Trump and will work tirelessly to re-elect him in 2020".
"She's not waiting around to see if Bernie's in the race, she's not waiting to see if there are other women", said Joe Trippi, a longtime campaign manager and Democratic political consultant. Tom Steyer, a liberal billionaire from California, is also considering a run for president and will travel to the caucus and primary states of Iowa, New Hampshire and Nevada early this year.
Warren is the most prominent Democrat yet to make a move toward a presidential bid and has always been a favorite target of President Donald Trump.
Warren's event started at 6 p.m., and there were lines of people ready to hear what the senator had to say.
Outside Warren's debut event on Friday night, Natalie Wertz, 29, who was waiting for the candidate with a friend - both of them having purchased pink T-shirts emblazoned with Warren's de facto slogan, "Nevertheless, she persisted" - spoke confidently of Warren's potential as a candidate.
On December 31, Warren announced on Twitter and her website that she'd be launching an exploratory committee for president. But this trip offered the first glimpse of what she may look like as a 2020 candidate. After just one day of campaigning, Warren had already lost her voice and had to address a group of supporters with a hoarse throat. "You would have to ask her psychiatrist". "I don't have the power to do that". "Meanwhile, a September poll indicated that MA voters were more enthusiastic about Patrick making a White House bid than Warren".
Kirsten Gillibrand, a senator from NY and former lawyer, is being touted as a contender but may be on the outer with some influential Democrats after she said Bill Clinton should have resigned over the Monica Lewinsky scandal.