The United boss said: "We are going to try".
"If we draw [the gap] is nine points if we lose it is 12", he said.
Mourinho and Guardiola have clashed a number of times over the years, dating back to their El Classico days when they were in charge at Real Madrid and Barcelona respectively.
"All the derbies are special, I think in Spain there's more noise [in the media] than here, before the game especially, but it's always special for everybody".
"But now we have got some good results in the last few games and we just have to keep working hard every day and go game by game".
"If you want to speak about their football potential we can speak and football potential starts with investment after that of course there is a quality of the work, of the organisation, I think that is untouchable".
"We are always ready to compete and need to take advantage of the good momentum of the team at the moment".
Can United put in that kind of performance again, or will City blow them away like they have nearly every team this season?
"All derbies are special, I think in Spain there is more noise than here but special, special for everybody", he said. "The top teams, you can not imagine and think about it, play amazingly for 90 minutes and they don't have chances". "We can't talk about luck because everyone makes their own luck but we gave them the victory". "But Manchester City are a very powerful team".
The report goes on to claim that the player rarely speaks to his United teammates, save Juan Mata, David de Gea and Romelu Lukaku, a fact they find very odd.
"So if we keep conceding goals before the opponent we will arrive at the day where we can not come back so we have to make sure that we grow up, not just in our approach, but also in our compactness in order to start matches well". "I don't know his answer".