Under Senate rules, the key vote on McConnell's cloture motion will take place one hour after the Senate convenes Friday.
If that vote is successful, it would trigger up to 30 hours of additional debate and then a final confirmation vote, which could put Judge Kavanaugh on the Supreme Court before the next cases are heard Monday.
Five days after the FBI began its investigation into Supreme Court nominee Brett Kavanaugh and the sexual assault allegations made against him by Dr. Christine Blasey Ford, the probe is nearing its end.
Susan Collins of Maine, Jeff Flake of Arizona and Lisa Murkowski of Alaska are the only Republicans in the chamber known to be wavering in their support for Mr Trump's candidate.
Speaking at a campaign rally Tuesday night, Trump cast doubt on Ford's testimony before the Senate Judiciary Committee by mocking her for not knowing the answers to questions such as how she had gotten to the high school party in the 1980s where she says Kavanaugh sexually assaulted her, an allegation he has repeatedly denied.
Federal Bureau of Investigation agents had been sent back to update Judge Kavanaugh's file after sexual misconduct allegations were lodged last month against him, stemming from high school and college parties more than 30 years ago.
The FBI did interview Deborah Ramirez, another woman who accuses Kavanaugh of sexual assault. And Democrats argued that the investigation has been insufficient, lacking interviews with her, with Kavanaugh and others who Kavanaugh's accusers have said could have knowledge about the alleged incidents. "'I don't remember, '" Trump said.
"With all of that you can not say that we've done anything but be respectful, and I do".
He went on to say: "A man's life is in tatters".
And speaking at an event hosted by The Atlantic magazine, Trump ally Senator Lindsey Graham of SC said he "didn't particularly like" the president's remarks, adding, "I would tell him, knock it off". Republicans argue Ford had her say when she testified on Capitol Hill last week.
"I'm of the view that whatever could be made public should be, but that would be well outside the normal way these things are treated", said Republican senator Roy Bunt.
They said Kavanaugh 'displayed a lack of judicial temperament that would be disqualifying for any court, and certainly for election to the highest court of the land'. The goal: to shed light on Ford's accusation that Kavanaugh pinned her down and groped her in 1982.
The Senate Judiciary Committee expected to receive the report from the FBI Wednesday evening.
"We want to be careful not to fully characterize what is in the report, but we are going full steam ahead and have full confidence in his nomination", the official said.
Also interviewed was Tim Gaudette, a high school classmate of Kavanaugh.
"An FBI supplemental background investigation that did not include an interview of Dr. Christine Blasey Ford - nor the witnesses who corroborate her testimony - can not be called an investigation". Flake is a key GOP vote in the confirmation battle, and while he said last week he would vote to confirm Kavanaugh, he also called for an expanded FBI investigation that resulted in a one-week delay. I don't know. Where's the house?