Mr McCain died this morning surrounded by his family, according to a short statement released by his office. In 2008, he won the Republican nomination, only to see his hopes dashed by the phenomenon that was Barack Obama and a crumbling U.S. economy.
Following the news that longtime Arizona senator and Vietnam War veteran John McCain passed away on Saturday, teams and athletes around the state offered their thoughts.
On Capitol Hill, McCain became close friends with Senator Lindsey Graham and Joe Lieberman - a trio dubbed the "Three Amigos".
Near the driveway to his ranch a sign read "Sen McCain, thank you for your service". "We honour his lifetime of service to this nation in our military and in public life". The president said he liked those who were not captured better.
But we shared, for all our differences, a fidelity to something higher - the ideals for which generations of Americans and immigrants alike have fought, marched, and sacrificed.
'To fear the world we have organized and led for three-quarters of a century, to abandon the ideals we have advanced around the globe, to refuse the obligations of worldwide leadership and our duty to remain "the last best hope of Earth" for the sake of some half-baked, spurious nationalism cooked up by people who would rather find scapegoats than solve problems, is as unpatriotic as an attachment to any other exhausted dogma of the past that Americans consigned to the ash heap of history, ' he said previous year in Philadelphia.
But a review of McCain's life shows that his story is one of survival. Character. Courage. Integrity. Honour.
"A life lived embodying those truths casts a long, long shadow".
When he was finally released and able to return home years later, Senator McCain continued his service by regaining his naval flight status. His impact on America hasn't ended.
McCain was finally freed after five and a half years, two of which he spent in solitary confinement.
"My father is gone, and I miss him as only an adoring daughter can", McCain concluded.
McCain found Putin's growing influence on the world stage particularly worrisome.
Bush also released a statement on Mr McCain's passing, writing how hard it is to imagine that such a vivid life has ended.
"I think that's unfortunate because he had some unusual people around him and...disloyal people, and you know, I don't say that as like hate speech or griping about it, it's just a fact they were just some not nice people".
President Reuven Rivlin bid farewell to the "great leader", whom he hailed as a "defender of his people, a man of strong values, and a true supporter of Israel". He was a public servant in the finest traditions of our country.
John McCain is greeted by President Richard Nixon 1973 after he spending more than five years in a Vietnamese prisoner of war camp. "I'm going to continue to serve as governor as long as the voters will let me", he said.
Mr McCain's 2008 running mate said: "Today we lost an American original. Sen".
"John McCain was my friend".
"I'll remember the good times that's for darn sure", Palin said.
McCain had not been present in the Senate since December.
Numerous prison cells were preserved and are still standing, although it's unclear if the cell where McCain was held is still among them.
"I hope I don't become a snob", McCain said after winning a seat in the upper chamber. "I will always be especially grateful for his leadership in our successful efforts to normalise relations with Vietnam".
McCain was a newcomer to Arizona when he won an open seat for the state in the House of Representatives. John McCain was a giant of our time not just for the things he achieved, but for who he was and what he fought for all his life.
Former President George W Bush described McCain, his one-time political rival, as a "man of deep conviction and a patriot of the highest order". Phoenix Suns star Devin Booker has revealed how he, too, is one with the country by sending out a heartfelt tweet expressing his grief on the loss of one of America's most prominent political figures.