Erie County Executive Kathy Dahlkemper, who has been part of a national task force on opioids, said this helps to keep the drugs out of the wrong hands.
Saturday is one of two annual "Drug Take Back" events throughout the state, this year's campaign is called 'Dose of Reality'.
"They are even turning in pet medications", said Leslie Knight, a Maine Medical Center registered nurse who was there with about a half-dozen of her nursing colleagues. The study showed majority of abused prescription drugs were taken from medicine cabinets of family and friends.
But, even with the Take Back Program's success, the pill problem has continued to get worse over the years.
Last October, National Take Back collected nationally 456 tons of unwanted prescriptions.
Police hope that inspiring people to return any medications they don't plan on using will reduce the rate of opioid overdose deaths.
Thousands of pounds of prescription drugs were taken off the streets thanks to the Drug Enforcement Agency (DEA).
The sites accept pills, tablets, and patches but not liquids or syringes. "So when they have this we're able to bring it here where we know it's safe and will be taken care of".
"We're not out to get people in trouble for disposing of it properly", he said.
Along with Gadsden County and Wakulla County Sheriff's Office, the Tallahassee Police Department collected bags from the community filled with dozens of prescription drugs.