The French tactician was expected to field his strongest possible squad against a team led by Jose Mourinho, a man he has often failed to conquer in several league meetings both as manager of Chelsea and now, Manchester United, especially in their last meeting in the current dispensation.
United haven't completed a league double over the Gunners since the 2011-12 Premier League season.
However, with Arsenal concentrating on the Europa League, this game sandwiched in between the two semi-finals against Atletico Madrid, and neither team with much to play for in the Premier League, this will be a strangely decaffeinated end to two rivalries that were once so heated.
The quandary for Bellerin will be to reel in his electric dashed down the United left, keeping Sanchez as his bedfellow for the majority of the 90 minutes at Old Trafford.
The Chile worldwide left the Emirates Stadium in January after three-and-a-half years at the club, and is expected to line out for Jose Mourinho's Manchester United at Old Trafford. Goalkeeper Sergio Romero however, is out with a knee problem.
Pierre-Emerick Aubameyang will likely come into the starting XI either on the left-wing or in place of Alexandre Lacazette up front, with Aaron Ramsey, Mesut Ozil and Jack Wilshere all questionable starters.
In terms of injuries, the Gunner will still miss out on Cazorla and Mohamed Eleny.
Wenger looked bemused when asked yesterday if he could be friends with Mourinho, eventually saying "it depends", but was also far more willing than usual to praise his rival's achievements.
At Arsenal, Wenger is one of the best-paid football managers in the world as he makes close to £10 million a year.
Nor are his teams especially when the north Londoners roll into town.
Perhaps Arsene Wenger's most significant triumph at Old Trafford as his side would go on to contest the rest of the campaign unbeaten in their famous "Invincibles" season.