The Manchester United striker was on target after just five minutes against Swansea to join the list that includes the likes of Thierry Henry and Alan Shearer.
Sanchez set up Lukaku's goal before scoring his first since the 2-0 win over Huddersfield Town last month, in what was arguably his best performance since signing from Arsenal in January.
The 27-year-old's goalkeeper adversary Ederson has also been in fine form this campaign, conceding only 20 goals for Manchester City, though De Gea has now kept two more clean sheets than the Brazilian.
The Chile worldwide made it 2-0 for United in the 20th minute after Jesse Lingard cut open the City defence with an incisive pass that found Sanchez, who slotted into the bottom corner from 18-yards out.
Tammy Abraham makes United uncomfortable in the second-halfJose Mourinho cut a concerned figure in the second-half!
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The Premier League returns this weekend after the worldwide break so now we don't have much longer to wait before Manchester City are officially crowned champions.
The lanky forward, however, showed his footwork isn't half-bad either as he turned his marker inside out to seemingly score, only for United's custodian to reinforce his credentials as the world's premier shot-stopper with a jaw-dropping save. By that time, United fans in a sell-out crowd had started to slip off home. "Maybe one more goal and game over and the first half was probably one of the best we played here". However, once again they had to call upon their goalkeeper to save them.
Huzzah! Another long and boring global break, the last one of this season, is just about over now as we have Premier League football to focus on again.
He does at least give The Swans credit for our fightback in the second half.
Everton's 4-0 win in this fixture last season is Pep Guardiola's heaviest ever league defeat as a manager and one of just three occasions in his managerial career he has lost by four goals.
"The second half they improved but we let it go".
"Every point is vital because we want to stay in second place".
"I'm really happy for Alexis he got a lot of stick from people but the hard work pays off", the 24-year-old told MUTV.
Swansea, revitalised under Jose Mourinho's friend and compatriot Carlos Carvalhal, remain three points above the relegation zone but drop down a place to 15th. The Premier League action returns after a two-week break due to global friendly matches ahead of the World Cup this summer.